New healthcare, human, and social service providers are regularly added as members of Nexus SD. The following organizations are currently participating in the Nexus SD network.

• Abbott House
• Active Generations
• Avera
• Big Brothers, Big Sisters of the Black Hills
• Big Friend Little Friend of the Mitchell Area
• Black Hills Pediatric Dentistry
• Black Hills Special Services Cooperative
• Caminando Juntos
• Community Action for Veterans
• Face It TOGETHER
• Fall River Health Services
• Feeding South Dakota
• Ginny's Safe House
• Great Plains Tribal Leaders Health Board
• Health Connect of South Dakota
• Helpline Center
• Legacy Foundation (Owen's Outfitters)
• Meade County Senior Center
• Mobridge Regional Hospital and Clinics
• Monument Health
• Oaye Luta Okolakiciye
• Philip Health Services
• Project Recovery
• Rapid City Fire Department Mobile Integrated Health Program
• Rural Office of Community Services
• Salvation Army of Mitchell
• Seeds of Eden
• Sequel, Inc
• Sioux Falls Housing and Redevelopment Commissions
• South Dakota Department of Health, Office of Disease Prevention Services
• South Dakota Urban Indian Health
• Spearfish Senior Center
• Volunteers of America Northern Rockies
• Western SD Community Action
• West River Mental Health